C Villaverde, A I Alvarez, J L del Estal, J G Prieto
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引用次数: 6
摘要
研究了大鼠离体肠细胞对阿苯达唑(ABZ)和甲苯达唑(MBZ)的摄取。这些药物，广泛用于口服驱虫药，表现出稀缺的水溶性，减少其吸收的口腔。本研究旨在评估从上绒毛到隐绒毛分离的不同肠细胞群中ABZ和MBZ的捕获。两种药物的吸收实验浓度范围均为10-500微米，溶剂均为DMSO。结果表明，ABZ和MBZ在10 ~ 100 μ m浓度下存在被动吸收机制，最大摄入量约为20 μ m /mg蛋白质。在细胞群分析方面没有发现差异。在达到最大平台之前，MBZ的药物摄取水平似乎高于ABZ。
Albendazole and mebendazole uptake by isolated enterocytes.
Uptake of albendazole (ABZ) and mebendazole (MBZ) by isolated rat enterocytes was carried out. These drugs, widely used oral anthelmintics, exhibit a scarce water solubility which reduce its absorption by the oral tract. The present study was designed to assess the captation for ABZ and MBZ in different enterocyte populations isolated from upper to crypt villus. The concentration range used for the absorption experiments was within 10-500 microM for both drugs, using DMSO as solvent. The results obtained show the existence of a passive mechanism for the uptake of ABZ and MBZ at concentrations between 10 and 100 microM, with a maximum intake value around 20 microM/mg protein. No differences were found with respect to the cell populations analyzed. The drug uptake levels seem to be higher for MBZ than for ABZ prior to reaching the maximum plateau.
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