Antiulcer activity of hydroalcoholic extract of Bombacopsis glabra (Pasq.) A. Robyns. Leaves (Bombacaceae) in rat

The purpose of this study was to investigate the activity of the hydroalcoholic extract ofBombacopsis glabra leaves in rat. The mucoprotector effect of B. glabra leaves hydroalcoholic extract was studied by evaluating its ability to protect the mucosa from aggression of repeated oral administration of indomethacin at a dose of 30 mg/kg while pylorus ligature was used to study its anti-secretory effect. The results show that hydroalcoholic extract of the leaves of B. glabra, at doses 300 and 600mg/kg, decrease the surface area of lesions induced by indomethacin from 6.2 observed in the control group animals to 2.51 and 1.19 0.073 mm² respectively, in the treated animals (p 0.05). The extract decreases gastric acidity by increasing the pH of the gastric content from 1.7 0.03 of the control animals to 2.27 3.59 0.11 of the animals that received the extract at dose 300 and 600mg/kg respectively (p<0.05). These results show that the hydroalcoholic extract of B. glabra leaves possesses an anti-secretory effect and acts as a mucoprotector, and therefore has an antiulcer activity. The alkaloids, flavonoids, tannins, or polysaccharides in the extract could be responsible for this activity.