{"title":"心肌细胞环形多细胞聚集体的形成","authors":"T. Masuda, Natsuki Takei, F. Arai","doi":"10.1109/MHS.2011.6102151","DOIUrl":null,"url":null,"abstract":"We have proposed a unique multicellular aggregate formation platform that utilizes a maskless gray-scale photolithography. The cellular aggregate formed using this platform has a toroidal-like geometry and includes a micro-pore that facilitates the supply of the oxygen and growth factors and expels waste products. The toroidal multicellular aggregates were easily and non-invasively retrieved from the PDMS platform. A P19.CL6 toroidal multicellular aggregate, which indicates that most of the cells in the aggregate (> 95%) were still alive after 3 days of culture. By directed assembly of the toroidal multicellular aggregate, the micro-pore can be used as a communicated channel for vascularization and neurogenesis.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"45 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formation of toroidal multicellular aggregate of cardiomyocytes\",\"authors\":\"T. Masuda, Natsuki Takei, F. Arai\",\"doi\":\"10.1109/MHS.2011.6102151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We have proposed a unique multicellular aggregate formation platform that utilizes a maskless gray-scale photolithography. The cellular aggregate formed using this platform has a toroidal-like geometry and includes a micro-pore that facilitates the supply of the oxygen and growth factors and expels waste products. The toroidal multicellular aggregates were easily and non-invasively retrieved from the PDMS platform. A P19.CL6 toroidal multicellular aggregate, which indicates that most of the cells in the aggregate (> 95%) were still alive after 3 days of culture. By directed assembly of the toroidal multicellular aggregate, the micro-pore can be used as a communicated channel for vascularization and neurogenesis.\",\"PeriodicalId\":286457,\"journal\":{\"name\":\"2011 International Symposium on Micro-NanoMechatronics and Human Science\",\"volume\":\"45 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2011 International Symposium on Micro-NanoMechatronics and Human Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/MHS.2011.6102151\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2011 International Symposium on Micro-NanoMechatronics and Human Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MHS.2011.6102151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Formation of toroidal multicellular aggregate of cardiomyocytes
We have proposed a unique multicellular aggregate formation platform that utilizes a maskless gray-scale photolithography. The cellular aggregate formed using this platform has a toroidal-like geometry and includes a micro-pore that facilitates the supply of the oxygen and growth factors and expels waste products. The toroidal multicellular aggregates were easily and non-invasively retrieved from the PDMS platform. A P19.CL6 toroidal multicellular aggregate, which indicates that most of the cells in the aggregate (> 95%) were still alive after 3 days of culture. By directed assembly of the toroidal multicellular aggregate, the micro-pore can be used as a communicated channel for vascularization and neurogenesis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
