A. Abedi, Serhat Çelik, Zeynep Dilan Özçelik Yılmaz, Z. Güven, H. Akalın, L. Kaynar
{"title":"异基因造血干细胞移植后致供体细胞白血病1例报告","authors":"A. Abedi, Serhat Çelik, Zeynep Dilan Özçelik Yılmaz, Z. Güven, H. Akalın, L. Kaynar","doi":"10.51271/jchor-0011","DOIUrl":null,"url":null,"abstract":"A 48-year-old man was diagnosed Acute myeloid leukemia with FLT3 ITD positive and PML/RAR?- negative. Remission was \nachieved after induction and consolidation chemotherapy. Allogeneic hematopoietic stem cell transplantation was performed \nfrom his full matched sibling donor. He relapsed after 5 years and his bone marrow examination revealed PML/RAR?-\npositive Acute promyelocytic leukemia. t(15:17) was positive and FLT-3 ITD was negative. Cytogenetic and molecular analysis \nconfirmed donor cell origin. Donor didn’t develop Acute promyelocytic leukemia.","PeriodicalId":171029,"journal":{"name":"Journal of Current Hematology & Oncology Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Donor cell leukemia after allogeneic hematopoietic stem cell transplantation: a case report\",\"authors\":\"A. Abedi, Serhat Çelik, Zeynep Dilan Özçelik Yılmaz, Z. Güven, H. Akalın, L. Kaynar\",\"doi\":\"10.51271/jchor-0011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 48-year-old man was diagnosed Acute myeloid leukemia with FLT3 ITD positive and PML/RAR?- negative. Remission was \\nachieved after induction and consolidation chemotherapy. Allogeneic hematopoietic stem cell transplantation was performed \\nfrom his full matched sibling donor. He relapsed after 5 years and his bone marrow examination revealed PML/RAR?-\\npositive Acute promyelocytic leukemia. t(15:17) was positive and FLT-3 ITD was negative. Cytogenetic and molecular analysis \\nconfirmed donor cell origin. Donor didn’t develop Acute promyelocytic leukemia.\",\"PeriodicalId\":171029,\"journal\":{\"name\":\"Journal of Current Hematology & Oncology Research\",\"volume\":\"34 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Current Hematology & Oncology Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51271/jchor-0011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Current Hematology & Oncology Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51271/jchor-0011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Donor cell leukemia after allogeneic hematopoietic stem cell transplantation: a case report
A 48-year-old man was diagnosed Acute myeloid leukemia with FLT3 ITD positive and PML/RAR?- negative. Remission was
achieved after induction and consolidation chemotherapy. Allogeneic hematopoietic stem cell transplantation was performed
from his full matched sibling donor. He relapsed after 5 years and his bone marrow examination revealed PML/RAR?-
positive Acute promyelocytic leukemia. t(15:17) was positive and FLT-3 ITD was negative. Cytogenetic and molecular analysis
confirmed donor cell origin. Donor didn’t develop Acute promyelocytic leukemia.
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