长期乙醛中毒肝脏谷胱甘肽含量降低及抗氧化酶活性变化。

Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis Pub Date : 1992-01-01

A Hołownia, M Chwiećko, D Pawłowska, R Farbiszewski

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引用次数: 0

摘要

研究了乙醛连续4周对大鼠肝脏抗氧化保护系统的影响。试验组肝脏SOD活性由对照组542.4 U/g降至411.2 U/g(降低24%)。GSH-Px活性几乎没有变化，肝脏CAT活性显著降低(35%)。乙酰胆碱处理后肝脏非蛋白中巯基化合物含量由对照组的4.22 μ mol/g降低至2.86 μ mol/g(23%)。此外，乙醛处理导致肝脏MDA水平显著升高(增加78%)。

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The diminution of liver glutathione content and changes in activities of antioxidant enzymes in long-term acetaldehyde poisoning.

The effect of acetaldehyde administration for 4 weeks on antioxidant protection systems was investigated in liver of rats. Liver SOD activity was decreased from control value 542.4 U/g of tissue to 411.2 U/g of tissue in experimental group (24% decrease). GSH-Px activity was practically unchanged and liver CAT activity was significantly decreased (35%). Sulfhydryl compounds in liver non-proteins following ACH treatment were decreased from 4.22 mumol/g of tissue in control group to 2.86 mumol/g of tissue (23%). Furthermore acetaldehyde treatment caused significant increase in MDA level in liver (78% increase).

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Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis

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