The Role of Aflatoxins in Aspergillus flavus Resistance to Stress

Aspergillus section Flavi produce the aflatoxins, secondary metabolites toxic to humans and animals. Why do these fungi produce aflatoxins? They do not have a clear role in pathogenicity or in niche competition. Aspergillus employs a considerable amount of energy to synthesize them: more than 20 enzymatic catalyzes are needed. Within the A. flavus species, all opportunistic pathogens of maize, more than half of the natural population are atoxigenic, indicating that aflatoxins are not so obviously linked to an enhancement of population fitness. The perspective changes in A. parasiticus, pathogen to peanuts, where more than 90% of the natural population produce the four aflatoxins. In this chapter, we aim to discuss our recent hypothesis that aflatoxins act as antioxidants providing more time to Aspergillus to “escape” an exploited substrate, that in the meanwhile is “fully charged” with reactive oxygen species and oxylipins.