狂犬病传播动力学与控制的数学分析

Suleman Adamu Bukari, Baba Seidu, M. I. Daabo
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引用次数: 0

摘要

狂犬病是一种危险的疾病,比任何其他传染病夺去许多人的生命,但它却被低估了。这是由于人们对病毒的无数传播途径知之甚少。提出了一种确定性模型来研究狂犬病病毒在家养狗(犬科)和人类(智人)中的传播。我们仔细研究了狂犬病病毒在狗与狗、狗与人之间的传播,并首次研究了人与人之间的传播。通过敏感性分析确定各参数对狂犬病传播的影响最大。确定了无狂犬病平衡点和地方性平衡点,并得到平衡点稳定的条件。稳定条件提供了疾病持续存在或被根除的条件。利用MATLAB中的ode45程序对该模型进行了数值求解。研究表明,要根除狂犬病,必须降低犬只招募率,增加对暴露和感染犬只的扑杀,并针对犬只群体进行大规模疫苗接种。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mathematical Analysis of Rabies Transmission Dynamics and Control
Rabies is a dangerous disease that kills many people than any other communicable disease and yet it is underrated. This results from the little knowledge on the myriad ways of transmission of the virus. A deterministic model is proposed to study the spread of the rabies virus in both domestic dogs (Canis familiaries) and humans (Homo sapiens). We elaborately studied the spread of the rabies virus from dogs to-dogs, dogs-to-humans and for the first time, humans-to-humans. Sensitivity analysis is performed to determine the influence of various parameters on the transmission of rabies the most. The rabies-free equilibrium and the endemic equilibrium points were determined and the conditions under which the equilibria are stable were also obtained. The stability conditions provide the conditions under which the disease will persist or get to be eradicated. Numerical solutions of the model were obtained using the ode45 routine in MATLAB. The study demonstrated that for rabies to be eradicated, the rate at which dogs are recruited must be decreased, culling of exposed and infected dogs should be increased and mass vaccination of the dog population should be targeted.
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