印度南部一5岁男童以腹泻为唯一症状的副伤寒病例报告

Vannala Raju, Narayana Lunavath, L. Makam, G. M. Varma
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摘要

副伤寒是一种由副伤寒沙门氏菌血清型a、B或c引起的全身性细菌感染。它主要与到流行地区旅行有关,但也可在非流行地区零星发生。虽然这种疾病在成人中更常见,但它也可能发生在儿童身上,并且表现可能是可变的。不分离病原菌,在临床上很难区分伤寒和副伤寒。我们报告一例来自南印度特伦甘纳邦的5岁男孩,他表现为每天8至10次水样腹泻和腹部不适,持续5天。在就诊时,患儿有一些脱水和非常差的口服摄入量。患儿对标准急性胃肠炎无反应,伴有脱水处理,并持续出现稀便水样。血常规、尿、便镜检显示正常。在患病第二周的进一步评估显示粪便培养副伤寒,并且儿童在开始使用头孢噻肟敏感抗生素注射3天后开始有反应。然而,该儿童没有副伤寒引起的其他典型症状,如发烧、呕吐或玫瑰斑。其他的传统调查如血培养和尿培养都是阴性的。该病例强调了将副伤寒视为持续性腹泻的潜在原因的重要性,即使在幼儿中也是如此,以及及时诊断和使用适当抗生素治疗的重要性,特别是在没有经典临床或实验室发现的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case of Paratyphoid with Diarrhea as the Only Symptom in a 5 Year Old Boy from Southern Part of India
Paratyphoid fever is a systemic bacterial infection caused by bacteria Salmonella paratyphi serovars A, B, or C. It is most associated with travel to endemic areas but can occur sporadically in non-endemic areas. While the disease is more commonly seen in adults, it can occur in children, and the presentation can be variable. It is clinically difficult to differentiate Typhoid from Paratyphoid without isolation of organism. We present a case of a 5-year-old boy, from Telangana state of South India, who presented with watery diarrhea of 8 to 10 episodes per day and abdominal discomfort for 5 days. At presentation child had some dehydration and very poor oral intake. Child did not respond to standard acute gastroenteritis with some dehydration management and continued to have persistent loose watery stools. Routine blood investigations, urine and stool microscopy revealed normal study. Further evaluation in the second week of illness revealed paratyphi on stool culture, and the child started to respondwithsensitive antibiotic cefotaximeinjections after 3 days of starting. However the child did not have other classical symptoms caused by paratyphi, such as fever, vomiting, or rose spots. Other classical investigations like blood culture and urine culture were negative. This case highlights the importance of considering paratyphoid as a potential cause for persistent diarrhea, even in young children, and the importance of prompt diagnosis and treatment with appropriate antibiotics, especially in the absence of classical clinical or laboratory findings.
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