Evaluation of Hyperprolactinemia and Thyroid Disorder among Women with Dysfunctional Uterine Bleeding at Tertiary Care Hospital of western Rajasthan

Background: Women suffers 10 times more with thyroid disorders than men. Alterations in menstrual cycle alters thyroid function which could be either hypo or hyper thyroidism. Abnormal increase in serum prolactin level can cause disturbance in follicle maturation and corpus luteum function, and can lead to inhibition of normal secretion of GR hormone in hypothalamus which results in anovulation. The aim of the present study was to assess the thyroid and the prolactin levels among the women with dysfunctional uterine bleeding at tertiary care Hospital of western Rajasthan. Methods: An observational study was conducted for a period two years i.e from 2020 to 2022 in our institution at the gynaecology OPD with help of pathology department. 250 Patients with the complaints of dysfunctional uterine bleeding of age group between 25 to 70 years were included in the study. Estimation of Free T3, Free T4, TSH and prolactin was done by chemiluminescent immunoassay for the patients. Results: The mean TSH levels among the DUB cases was high. Similarly, hyperprolactinemia was found in cases and the mean prolactin levels were higher in cases. Significantly strong positive correlation between thyroid function and prolactin with p value <0.0001 was found.which indicates that as the TSH level increases prolactin levels also increases. Conclusions: Early detection of hypothyroidism in DUB cases can save the patient from recurrent curettage and at times hysterectomy. The financial implications of screening for prolactin/thyroid hormone abnormalities will have to be evaluated before a general recommendation can be made.