利用比较基因组学预测蓝藻的操纵子

2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05) Pub Date : 2005-08-08 DOI:10.1109/CSBW.2005.101

Natalia Khuri, N. S. Rao

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引用次数: 1

摘要

在这项工作中，我们对8种公开可用的蓝藻基因组和广泛研究的大肠杆菌K12的基因组组织进行了全面分析。我们的比较揭示了不同微生物基因组组织的惊人相似性。我们研究了假设CDS的方向，以及整个基因组中相邻假设CDS之间的距离分布模式，以及操纵子内和跨操纵子边界的基因之间的距离分布模式。我们的研究结果使我们能够计算出基因对属于同一操纵子的距离对数似然，并将这一指标应用于预测两种新测序的蓝藻基因组(聚球菌OS-A和OS-B’)的操纵子。

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Operon prediction in cyanobacteria using comparative genomics

In this work, we performed a comprehensive analysis of the genome organization of eight publicly available cyanobacterial genomes and of the extensively studied Escherichia coli K12. Our comparison revealed striking similarities in organization of different microbial genomes. We examined the orientation of putative CDS, and distance distribution patterns between adjacent putative CDS in the whole genome as well as between genes within operons and across operon borders. Our results enabled us to calculate distance log-likeihoods for gene pairs to be part of the same operon and to apply this metric to predict operons in two newly sequenced cyanobacterial genomes, Synechococcus OS-A and OS-B'.

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2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05)

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