Synthesis and Anti Proliferative Activity of Thiosemicarbazone and 4-Thiazolidinones

Thiosemicarbazone and 4-Thiazolidinones are heterocyclic compounds with a broad spectrum of biological activities such as anti-inflammatory, anti-viral, anti-bacterial, anti-fungal and anticancer. A series of ten derivatives of thiosemicarbazone and 4-thiazolidinones derivatives was synthesised and evaluated for their antiproliferative activity against human breast cancer cells (MCF-7). The structure of compounds was established by IR and 1HNMR spectral studies. The synthesized compounds possessed good to moderate anticancer activity using Adriamycin as a standard. Out of ten synthesized compounds eight have GI50 value of <10 µg/ml demonstrating their potential activity. TGI for compound 6d was found to be comparable to Adriamycin (<10 µg/ml).