基于模式识别的药物-药物相互作用诊断方法

R. Javed, T. Saba, Salman Humdullah, Nor Shahida MOHD JAMAIL, Mazhar Javed Awan
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引用次数: 15

摘要

诊断两种药物之间的相互作用是药物开发的一个重要步骤。许多医疗工具提供与DDI相关的完整记录。然而,这个工具的结果并不是很令人满意。主要目的是提出一种基于模式匹配的有效方法来识别两种药物之间的相互作用。在这项研究中,目标是从DrugBank收集数据,这是一个公开的来源。与药物相关的数据包括药物ID、药物名称和各种药物相互作用的句子。通过语料库中定义的药名字典识别药名,并根据给定的模式确定句子。这些句子将被视为输入数据,预处理步骤将在这些句子中执行。选择各种类型的特征进行机器学习分类。然后将所有属性分类到所需的类中。该方法在随机森林分类器上获得95.4%的准确率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Efficient Pattern Recognition Based Method for Drug-Drug Interaction Diagnosis
The diagnosis of interactions between two drugs is an essential procedure in drug development. Many medical tool’s offer inclusive records related to DDI. However, this tool’s results are not very satisfactory. The main aim is to propose an efficient approach based on pattern matching that identifies the interaction between two drugs. In this study, the goal is to collect the data from the DrugBank, which is a publicly available source. The drug-related data includes drug ID, drug names, and various kinds of sentences of drug-drug interaction. Drug names will be identified by drug names dictionary defined in the corpus, and sentences will be determined according to given patterns. These sentences will treat as input data, and preprocessing steps will perform in these sentences. Various types of features are selected for machine learning classification. Then all the attributes will be classified into desired classes. The proposed method gains 95.4% accuracy from the random forest classifier.
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