肿瘤内注射swcnts分散体的乳腺肿瘤异种移植物的体内微波介电光谱研究

2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC) Pub Date : 2013-05-06 DOI:10.1109/I2MTC.2013.6555652

Fuqiang Gao, S. Hagness, J. Booske, S. X. Xie, B. Sitharaman

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引用次数: 2

摘要

我们对具有单壁碳纳米管(SWCNTs)积累的小鼠乳腺肿瘤异种移植物的微波频率介电特性进行了初步的体内研究。将不同浓度的swcnts - dspe - peg分散体直接注射到22个肿瘤中。采用开放式同轴探针技术对注入前后介电特性(1-6 GHz)进行了表征。基线测量(假对照和仅PEG)也在12个肿瘤中进行。我们发现，注射100 μl的swcnts原液，浓度在3 ~ 7 mg/ml之间，至少有~10%的相对介电常数增强效应。

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In vivo microwave dielectric spectroscopy of breast tumor xenografts with intra-tumoral injections of SWCNT dispersions

We present a preliminary in vivo study of the microwave-frequency dielectric properties of mice breast tumor xenografts with accumulation of single-walled carbon nanotubes (SWCNTs). Dispersions of SWCNT-DSPE-PEG at various concentrations were injected directly into 22 tumors. Dielectric properties (1-6 GHz) before and after the injection were characterized using an open-ended coaxial probe technique. Baseline measurements (sham control and PEG only) were also conducted in 12 tumors. We found at least a ~10% relative permittivity enhancement effect upon injection of 100 μl of SWCNT stock solutions at concentrations ranging between 3 and 7 mg/ml.

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2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)

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