An adaptive scheme of controlling dosage and dosing interval in general anesthesia by model predictive control using anesthetic depth model

In this paper, we proposed a dosage control system for total intravenous anesthesia (TIVA) in order to help anesthe- siologists and enable to manage multiple operations remotely by one anesthesiologist. In the general anesthesia, constraints of a drug dosage and the value of biological information indicating anesthetic depth must be taken into account. Also, introduction time of anesthesia and time to awake after surgery is required to be short with satisfying above restrictions. Furthermore, if surgery periods are extended, anesthetic effect should be maintained during surgery. From this point of view, we proposed an adaptive scheme of controlling the dosage and the dosing interval by model predictive control in order to satisfy such complicated requirements.