Formulation development and evaluation of controlled release matrix tablets of glibenclamide

Matrix tablets were prepared by three different polymers as sustained-release agents, using Glibenclamide as a model drug. The aim of the present study was to formulate and evaluate the controlled release matrix tablets of Glibenclamide which is an antidiabetic drug which belongs to the second generation oral hypoglycemics. Three polymers were selected for this study- HPMC K 15, HPMC K 100 and EC in different drug: polymer ratio. The drug was identified by FTIR spectroscopic method. The pre compression and post compression parameters of all formulations were found to be within acceptable limit. The release rate of Glibenclamide from matrix tablets was studied using USP Dissolution Testing Apparatus type-I (Basket method). The formulation F6 which contained EC 50mg showed a maximum release of 99.28% in 24 hrs and revealed that EC was more effective in sustaining the drug release and therefore the formulation F6 selected as the optimized formulation. The in-vitro release data of optimized formulation was fit into various kinetic models, among the different models data of in-vitro release of best fit into Zero order kinetic model. The formulation best fit to Higuchi model showed that drug release from the prepared matrix tablets occurs via diffusion process.