甲下黑色素瘤1例临床分析

Y. Pavlov, V. V. Volkov, I. A. Gromov, A. A. Kholopov
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摘要

甲下黑色素瘤是一种罕见的恶性肿瘤,很少为人所知。它的位置使诊断困难,需要与甲癣、panaritium、血肿等病症鉴别。无症状的发病带来了更多的问题,即使是经验丰富的肿瘤学家在视觉检查时的错误率也达到25-40%,完全表现的黑色素瘤患者的平均预期寿命限制在3-4年。因此,我们提出一个临床病例,强调需要在门诊检查的甲下病变肿瘤警觉性。一名32岁的妇女来到接待处,抱怨她的左小脚趾伤口出血不愈合,相对无痛。这种情况与创伤有关,她自己治疗了大约一个月的伤口,用防腐剂“烧灼”伤口。在门诊治疗了一个肉芽肿伤口后,将材料送去进行组织学诊断,结果显示在活跃生长阶段存在无色素黑色素瘤。该妇女被紧急送往肿瘤科,在那里成功地进行了五指摘除和腹股沟-髂淋巴结切除术。此后,病情保持稳定,但14个月后,术后瘢痕区域形成。一项新的手术材料的研究证实了恶性黑色素瘤复发并伴有Clark侵袭2级。在我们看来,门诊外科医生不应该延误所有溃疡和肉芽肿性病变的组织学检查,这将提高鉴别诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical case of a patient with subungual melanoma
Subungual melanoma is a rare malignant tumor, little known to practitioners. Its location makes diagnosis difficult and requires differentiation with conditions such as onychomycosis, panaritium, hematoma, etc. Unsymptomatic onset brings more problems, the error level during visual examination even among experienced oncologists reaches 25–40%, and the average life expectancy of patients with fully manifested melanoma is limited to 3–4 years.So we present a clinical case to emphasize the need for oncological alertness during an outpatient examination of the subungual lesions. A 32-year-old woman came to the reception complaining of a non-healing bleeding, relatively painless wound of the left little toe. The condition was associated with trauma, for about a month she treated the wound herself, “cauterizing” it with antiseptics.After outpatient treatment of a granulating wound, the material was sent for histological diagnosis, which showed the presence of pigmentless melanoma in the stage of active growth. The woman was urgently hospitalized in the oncology department, where 5th finger exarticulation and inguinal-iliac lymphadenectomy were performed successfully. After this, the condition remained stable, but 14 months later there was a formation in the area of the postoperative scar. A study of a new surgical material confirmed the recurrence of malignant melanoma with Clark invasion level 2.In our opinion, outpatient surgeons should not delay histological examination for all ulcerative and granulomatous lesions of the feet, which will improve the differential diagnosis.
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