α硫辛酸联合皮质类固醇激素改善脊髓感染性疾病预后(附10例研究)

Xin Wang, A. Hubbard, G. Tan
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引用次数: 0

摘要

脊髓炎,视神经脊髓炎(NMO)和多发性硬化症(MS)是临床上常见的脊髓感染性疾病,费用昂贵,进行性且常导致终身残疾。甲泼尼龙琥珀酸钠是一种皮质类固醇激素,是治疗中枢神经系统炎症的常规有效药物,尤其适用于多发性硬化症发作[1]。然而,长期和/或大剂量使用皮质类固醇激素会产生严重的副作用,如股骨头坏死、脑出血、血压和血糖不稳定、肾脏紊乱等[2]。因此,皮质类固醇激素治疗在临床应用上受到限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alpha Lipoic Acid (Ala) Combining with Corticosteroid Hormone Improves the Outcome of Infectious Diseases in Spinal Cord (10 Cases Study)
Myelitis, Neuromylitis Optica (NMO) and Multiple Sclerosis (MS) are clinic common infectious diseases in spinal cord that are costly, progressive and often cause life-time disabilities. Methylprednisolone Sodium Succinate, a corticosteroid hormone, is a routine effective therapeutic drug for center nerve system (CNS) inflammation, especially applied for MS attacks [1]. However, long term and/or high dose use of corticosteroid hormone has serious side effects such as osteonecrosis of femoral head, cerebral hemorrhage, unstable blood pressure and blood sugar, disorder of kidney [2]. Therefore, corticosteroid hormone therapy is limited on clinical application.
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