共振腔成像生物传感器

Proceedings of the Lightwave Technologies in Instrumentation and Measurement Conference, 2004. Pub Date : 2005-12-05 DOI:10.1109/LEOS.2005.1548113

D. A. Bergstein, R. Irani, M. F. Irani, Charles DeLisi, M. S. Unlu

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引用次数: 0

摘要

谐振腔成像生物传感器(RCIB)检测溶液中目标生物分子与固定在微阵列表面的探针生物分子之间的结合。红外光通过包含微阵列表面的Si/SiO/sub 2/ Bragg反射镜构成的1平方厘米的腔共振耦合。当探头光束的波长被扫描时，红外摄像机在每个像素处监测腔的透射率。目前的设置检测蚀刻在其中一个布拉格反射镜的SiO/ sub2 /表面上的5nm浮雕结构。RCIB通过提供高灵敏度、高通量和实时观察的结合，改进了现有的无标记生物传感技术。

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Resonant cavity imaging biosensor

The resonant cavity imaging biosensor (RCIB) detects binding between target biomolecules in solution and probe biomolecules fixed to a microarray surface. IR light couples resonantly through a 1 cm square cavity constructed from Si/SiO/sub 2/ Bragg mirrors that contains the microarray surface. As the wavelength of the probe beam is swept, an IR camera monitors cavity transmittance at each pixel. The current setup detects 5 nm relief structures etched in the SiO/sub 2/ surface of one of the Bragg mirrors. RCIB improves on existing label-free biosensing techniques by offering the combination of high sensitivity, high throughput, and real-time observation.

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Proceedings of the Lightwave Technologies in Instrumentation and Measurement Conference, 2004.

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