Сhylothorax

M. Opanasenko, B. М. Konik, S. Belokon', O. V. Tereshkovych, L. Levanda, S. Shalagay, M. Kalenychenko, M. Shamray, V. I. Lysenko
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An analysis was perfomed, which allows us to conclude that most often (10 cases, 47.6 %) chylothorax was diagnosed in women as a manifestation of lymphangioleiomyomatosis (LAM). It should be noted that in 4 (36.3 %) patients, LAM was diagnosed only by lung biopsy. In 2 (18.1 %) women, chylothorax was bilateral. In 6 (54.5 %) cases, a history of spontaneous pneumothorax (a characteristic diagnostic sign of LAM). The second place among the causes of chylothorax was by intrathoracic lymph node dissection during surgery for lung cancer. In all 3 (14.2 %) cases, the patients underwent left­sided pulmonectomy. Chylothorax usually developed by about 5—7 days, which coincided with the mobilization of patients and the restoration of adequate nutrition. In 2 (9.5 %) patients, the cause of chylothorax was damage to the thoracic duct during neurosurgical intervention through the transpleural approach. 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引用次数: 0

摘要

目的:根据自己的经验,确定和分析治疗乳糜胸的有效方法。材料和方法。在过去的15年里,在SI的外科治疗肺结核和侵入性诊断方法的基础上,“以乌克兰F.G. Yanovsky NAMS命名的国家生理学和肺病研究所”治疗了21例诊断为乳糜胸的患者。其中,以缺血性心脏病5例(23.8%)、妇科疾病7例(32.9%)、肥胖4例(18.8%)居多。结果和讨论。通过分析,我们得出结论:女性乳糜胸最常被诊断为淋巴管平滑肌瘤病(LAM)的表现(10例,47.6%)。值得注意的是,在4例(36.3%)患者中,LAM仅通过肺活检诊断。2例(18.1%)女性乳糜胸为双侧。6例(54.5%)有自发性气胸史(LAM的特征性诊断征象)。乳糜胸的第二大原因是肺癌手术时胸内淋巴结清扫。所有3例(14.2%)患者均行左侧肺切除术。乳糜胸通常在5-7天左右发生,这与患者的活动和营养恢复一致。在2例(9.5%)患者中,乳糜胸的原因是经胸膜入路神经外科干预时胸导管受损。这种乳糜胸的特点是病程严重,很快导致患者衰竭,需要立即手术干预,在损伤水平以下结扎胸导管。2例(9.5%)患者乳糜胸是特发性肺骨化的表现之一。值得注意的是,肺骨化的诊断是在活检标本的组织学检查后才确定的,而这类患者入院时诊断为复发性胸膜炎。在这两种情况下,有可能通过胸膜壁切除术和保守治疗来实现淋巴漏的停止。这些患者的一个特点是,即使乳糜胸消除,中度呼吸衰竭的表现仍然存在。淋巴增生性疾病中的乳糜胸- 2例(9.5%)是肿瘤过程的普遍结果,因此在诊断后仅进行胸膜穿刺和对症治疗。在任何情况下都不可能完全停止漏淋巴。1例(4.7%)患者,特发性右侧复发性乳糜胸伴中度肺门淋巴结病变。胸腔镜下胸内淋巴结活检辅以胸膜壁切除术。这使得有可能实现可靠的停止淋巴漏,然而,根据组织病理学研究的数据,只有反应性的非特异性变化出现在淋巴结中。另1例(4.7%),因慢性胸膜结核而行右侧胸膜壁切除术后第4天,手术一侧出现淋巴漏。短期保守治疗可取得积极效果。因此,治疗乳糜胸的总有效率为85.7%。结论。乳糜胸是一个复杂的医学问题,其有效的解决取决于保守和手术治疗的综合方法。乳糜胸最常见的病因是淋巴管平滑肌瘤病(47.6%)。乳糜胸临床总有效率为85.7%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Сhylothorax
Objective — to determine and analyze, on our own experience, effective methods of treating chylothorax. Materials and methods. For the last 15 years on the basis of the department of surgical treatment of tuberculosis and invasive diagnostic methods of the SI «National Institute of Phthisiology and Pulmono­logy named after F.G. Yanovsky NAMS of Ukraine» was treated 21 patients with a diagnosis of chylothorax. Among the concomitant pathologies, the following diseases were most often diagnosed: ischemic heart disease 5 (23.8 %) cases, gynecological diseases 7 (32.9 %), obesity 4 (18.8 %). Results and discussion. An analysis was perfomed, which allows us to conclude that most often (10 cases, 47.6 %) chylothorax was diagnosed in women as a manifestation of lymphangioleiomyomatosis (LAM). It should be noted that in 4 (36.3 %) patients, LAM was diagnosed only by lung biopsy. In 2 (18.1 %) women, chylothorax was bilateral. In 6 (54.5 %) cases, a history of spontaneous pneumothorax (a characteristic diagnostic sign of LAM). The second place among the causes of chylothorax was by intrathoracic lymph node dissection during surgery for lung cancer. In all 3 (14.2 %) cases, the patients underwent left­sided pulmonectomy. Chylothorax usually developed by about 5—7 days, which coincided with the mobilization of patients and the restoration of adequate nutrition. In 2 (9.5 %) patients, the cause of chylothorax was damage to the thoracic duct during neurosurgical intervention through the transpleural approach. Such chylothorax is characterized by an aggressive course, quickly leads to exhaustion of the patient and requires immediate surgical intervention to ligate the thoracic duct below the level of injury. In 2 (9.5 %) patients, chylothorax was one of the manifestations of idiopathic pulmonary ossification. It should be noted that the diagnosis of pulmonary ossification was established only after a histological examination of a biopsy specimen, while such patients were admitted to the clinic with a diagnosis of recurrent pleurisy. In both cases, it was possible to achieve cessation of lymphorrhea by using parietal pleurectomy and conservative therapy. A feature of these patients is the fact that even with the elimination of chylothorax, moderate manifestations of respiratory failure remained in them. Chylothorax in lymphoproliferative diseases — in 2 cases (9.5 %) was the result of the prevalence of the oncological process, and therefore after its diagnosis, only pleural punctures and symptomatic treatment were performed. In no case was it possible to achieve complete cessation of lymphorrhea. In 1 (4.7 %) patient, idiopathic right­sided recurrent chylothorax was observed with moderate hilar lymphadenopathy. Videothoracoscopic biopsy of the intrathoracic lymph nodes was supplemented with parietal pleurectomy. This made it possible to achieve a reliable cessation of lymphorrhea, however, according to the data of a histopathological study, only reactive nonspecific changes were presented in the lymph nodes. In another 1 (4.7 %) case, on the 4th day after right­sided parietal pleurectomy for chronic pleural tuberculosis, lymphorrhea developed on the side of the operation. Short­term conservative therapy made it possible to achieve a positive result.Thus, the overall effectiveness of the treatment of such a pathological condition as chylothorax was 85.7 %. Conclusions. Chylothorax is a complex medical problem, the effective solution of which depends on a complex of conservative and surgical methods of treatment.The most common cause of chylothorax is lymphangioleiomyomatosis (47.6 %). The overall effectiveness of chylothorax treatment in the clinic is 85.7 %.
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