多源生物通路巩固

2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) Pub Date : 1900-01-01 DOI:10.1109/GENSiPS.2011.6169447

Mark Doderer, Zachry Anguiano, U. Suresh, Ravi Dashnamoorthy, A. Bishop, Yidong Chen

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引用次数: 1

摘要

发现一组有序的差异基因表达的表型描述的典型方法是鉴定途径富集。在不同的数据库中存在许多高度相关或冗余的路径，这使得它们的整合成为解释这些结果时必不可少的步骤。探索了两种途径巩固的方法，一种是利用富集程度最高的途径的基因集来寻找在给定实验中也富集的相似途径。另一种方法只使用每个途径中的基因成员，这种方法发现了独立于任何给定实验的新生途径集群。独特的巩固结果从两种方法提出，展示其在生物学研究中的应用。

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Multisource biological pathway consolidation

A typical method to discover phenotypic descriptions of an ordered set of differential gene expressions is to identify pathway enrichments. There are many pathways that are highly related or maybe redundant across different databases making their consolidation an essential step when interpreting these results. Two methods of pathway consolidation are explored, one utilizes the gene set of the most enriched pathway to find similar pathways also enriched in a given experiment. The other method uses only the gene members in each pathway, this finds de novo pathway clusters independent of any given experiment. Unique consolidation results from both methods are presented, demonstrating their applications in biological studies.

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来源期刊

2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

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