{"title":"可溶性和固定化免疫球蛋白免疫剂量对抗体产生的影响。","authors":"Fekete tkf, F péterfy, J Cserhidy, A Benkó","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The role of the immunizing dose on antibody production was studied in rabbits. The humoral immune response to soluble and insoluble human IgG was evaluated by the measurement of the amount of specific antibodies. The immobilizations of antigen was made by antigen-antibody precipitation and attachment of the protein to polyacrylamide and agarose matrices. It was found, that the antibody production did not decrease when the antigen dose was reduced from 100 microng to 300 microng; application of the antigen in immobilized form did not enhance the antibody response.</p>","PeriodicalId":7910,"journal":{"name":"Annales immunologiae Hungaricae","volume":"18 ","pages":"105-8"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of the immunizing dose of soluble and immobilized immunglobulins on the production of antibodies.\",\"authors\":\"Fekete tkf, F péterfy, J Cserhidy, A Benkó\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The role of the immunizing dose on antibody production was studied in rabbits. The humoral immune response to soluble and insoluble human IgG was evaluated by the measurement of the amount of specific antibodies. The immobilizations of antigen was made by antigen-antibody precipitation and attachment of the protein to polyacrylamide and agarose matrices. It was found, that the antibody production did not decrease when the antigen dose was reduced from 100 microng to 300 microng; application of the antigen in immobilized form did not enhance the antibody response.</p>\",\"PeriodicalId\":7910,\"journal\":{\"name\":\"Annales immunologiae Hungaricae\",\"volume\":\"18 \",\"pages\":\"105-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales immunologiae Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales immunologiae Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of the immunizing dose of soluble and immobilized immunglobulins on the production of antibodies.
The role of the immunizing dose on antibody production was studied in rabbits. The humoral immune response to soluble and insoluble human IgG was evaluated by the measurement of the amount of specific antibodies. The immobilizations of antigen was made by antigen-antibody precipitation and attachment of the protein to polyacrylamide and agarose matrices. It was found, that the antibody production did not decrease when the antigen dose was reduced from 100 microng to 300 microng; application of the antigen in immobilized form did not enhance the antibody response.
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