谱系追踪阐明了发育中的心脏组织内巨噬细胞的细胞起源

The Journal of Cell Biology Pub Date : 2022-04-28 DOI:10.1083/jcb.202108093

Kuo Liu, Hengwei Jin, Muxue Tang, Shaohua Zhang, Xueying Tian, Mingjun Zhang, Ximeng Han, Xiuxiu Liu, Juan Tang, Wenjuan Pu, Yan Li, Lingjuan He, Zhongzhou Yang, K. O. Lui, Bin Zhou

{"title":"谱系追踪阐明了发育中的心脏组织内巨噬细胞的细胞起源","authors":"Kuo Liu, Hengwei Jin, Muxue Tang, Shaohua Zhang, Xueying Tian, Mingjun Zhang, Ximeng Han, Xiuxiu Liu, Juan Tang, Wenjuan Pu, Yan Li, Lingjuan He, Zhongzhou Yang, K. O. Lui, Bin Zhou","doi":"10.1083/jcb.202108093","DOIUrl":null,"url":null,"abstract":"Liu et al. reassess the cellular origin of tissue-resident macrophages in the developing heart. By generating new genetic tools, they reveal that cardiac macrophages are mainly derived from the hemogenic endothelium of yolk sac and aorta-gonad-mesonephros but not from the endocardium.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart\",\"authors\":\"Kuo Liu, Hengwei Jin, Muxue Tang, Shaohua Zhang, Xueying Tian, Mingjun Zhang, Ximeng Han, Xiuxiu Liu, Juan Tang, Wenjuan Pu, Yan Li, Lingjuan He, Zhongzhou Yang, K. O. Lui, Bin Zhou\",\"doi\":\"10.1083/jcb.202108093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Liu et al. reassess the cellular origin of tissue-resident macrophages in the developing heart. By generating new genetic tools, they reveal that cardiac macrophages are mainly derived from the hemogenic endothelium of yolk sac and aorta-gonad-mesonephros but not from the endocardium.\",\"PeriodicalId\":343306,\"journal\":{\"name\":\"The Journal of Cell Biology\",\"volume\":\"4 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Cell Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1083/jcb.202108093\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202108093","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 7

摘要

Liu等人重新评估了发育中的心脏组织巨噬细胞的细胞来源。通过建立新的遗传工具，他们揭示了心脏巨噬细胞主要来源于卵黄囊和主动脉-性腺-中肾的造血内皮，而不是来自心内膜。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart

Liu et al. reassess the cellular origin of tissue-resident macrophages in the developing heart. By generating new genetic tools, they reveal that cardiac macrophages are mainly derived from the hemogenic endothelium of yolk sac and aorta-gonad-mesonephros but not from the endocardium.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Journal of Cell Biology

自引率

0.00%

发文量