慢性萎缩性多软骨炎的皮肤表现及其与细胞凋亡的关系。

J H Saurat, G Noury-Duperrat, J Delanoë, S Kernbaum, J Frottier, A Puissant
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引用次数: 0

摘要

女,23岁,临床表现为复发性多软骨炎。本病包括右耳、鼻肋及喉软骨反复发炎。她还患有脚踝和手腕关节炎。她在患软骨病之前从未有过细胞萎缩。在每次软骨炎症反复发作之前,口腔和生殖器的糜烂与口疮相似。1例出现无菌性囊性脓疱和结节样红斑。本病例提出的问题是,这是从未报道过的两种疾病的关联,还是复发的多软骨炎可能有与肺萎接壤的皮肤病症状。后一种假设得到了支持:首先,复发性多软骨炎(口腔aphaphative、脓疱疹、结节性红斑、复发性血栓性静脉炎)病例中分别报告了aphaphysis的皮肤症状;其次是一个与我们非常相似的病例(Thivolet,见原文),显示了复发性多软骨炎的典型特征,并伴有完全的皮肤病学方面的aphaphsis。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Cutaneous manifestations of chronic atrophic polychondritis and their relation to aphtosis].

A young woman aged 23 showed the clinical feature of relapsing polychondritis. This disease included recurrent inflammation of right ear, nasal rib and larynx cartilages. She had also arthritis of ankle and wrist. She never had aphtosis before her cartilaginous disease. Buccal and genital erosions similar to aphtae occurred before each recurrent attack of cartilage inflammation. In one instance aseptic vesiculo-pustular and erythema nodosum like lesions occurred. This case raises the question of whether this is a never reported association of two diseases or relapsing polychondritis may have dermatological symptoms bordering aphtosis. The latter hypothesis is supported: firstly by the fact that skin symptoms of aphtosis had been reported separately in cases of relapsing polychondritis (buccal aphtae, pustular eruption, erythema nodosum, recurrent thrombophlebitis); secondly by a case very similar to our (Thivolet, see text) showing a typical feature of relapsing polychondritis with a complete dermatological aspect of aphtosis.

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