V-ATPase是lc3相关吞噬和非典型自噬的普遍调节因子

The Journal of Cell Biology Pub Date : 2022-05-05 DOI:10.1083/jcb.202105112

K. Hooper, E. Jacquin, Taoyingnan Li, Jonathan M Goodwin, J. Brumell, J. Durgan, O. Florey

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引用次数: 26

摘要

Hooper等人报道了V-ATPase在非典型自噬(包括lc3相关吞噬)激活中的作用和调控。他们揭示了V-ATPase V0-V1接合如何招募自噬蛋白ATG16L1来指导ATG8结合到单膜的新见解。

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V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy

Hooper et al. report on the role and regulation of V-ATPase in the activation of non-canonical autophagy, including LC3-associated phagocytosis. They reveal new insights into how V-ATPase V0-V1 engagement recruits the autophagy protein ATG16L1 to direct the conjugation of ATG8 to single membranes.

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The Journal of Cell Biology

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