可重构模拟VLSI的生物物理神经脉冲和爆发动力学

Theodore Yu, T. Sejnowski, G. Cauwenberghs
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引用次数: 5

摘要

我们研究了生物物理参数变化下的一系列神经动力学,在三个门控变量中实现了扩展的Morris-Lecar和Hodgkin-Huxley模型。在具有广义通道动力学和生物物理膜动力学的模拟VLSI可编程神经仿真平台NeuroDyn中进行了动力学仿真。我们提出了模拟和测量结果,并通过控制钙恢复的单个电导参数的变化,观察到在宽范围内的强直尖峰和固有破裂动力学的一致协议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biophysical neural spiking and bursting dynamics in reconfigurable analog VLSI
We study a range of neural dynamics under variations in biophysical parameters implementing extended Morris-Lecar and Hodgkin-Huxley models in three gating variables. The dynamics are emulated in NeuroDyn, an analog VLSI programmable neural emulation platform with generalized channel kinetics and biophysical membrane dynamics. We present simulation and measurement results and observe consistent agreement over a wide regime of tonic spiking and intrinsic bursting dynamics through the variation of a single conductance parameter governing calcium recovery.
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