微环境对酵母种群动态的影响

J. Trosset, Sami Tliba, A. E. Ati, H. Friha, E. Mogensen, Jawher Kahouli, Robin V. Lacombe, Ouerdia Arkoun, S. Diop, R. Ledesma-Amaro, I. Boussaada
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引用次数: 0

摘要

外部营养物质的丰富或缺乏是代谢的触发因素,特别是对于细菌、酵母、寄生虫或肿瘤等高度增殖的细胞。在有氧气存在的情况下,细胞通常采用高效代谢,以便在不良饮食条件下最大限度地提高能量产量。如果营养资源增加,代谢从高效代谢(呼吸)到低效代谢(发酵)的转变反映了生命系统优化适应度的最小成本原则。这就是众所周知的克拉布特里/沃伯格效应。确定一个描述细胞种群动态和输入生长条件的模型是本研究的目标。在好氧和微氧条件下,对crabtree阳性酵母-酵母菌进行了一系列生长实验,建立了原理证明。基于自回归方法建立了估计代谢移位的一般细胞生长模型。关键词:酵母,种群动态,建模,鉴定
本文章由计算机程序翻译,如有差异,请以英文原文为准。
INFLUENCE OF MICRO-ENVIRONMENT ON YEAST POPULATION DYNAMICS
Abundance or scarcity of external nutrients is a metabolic trigger, especially for highly proliferative cells such as bacteria, yeasts, parasites or tumors. In presence of oxygen cells usually adopt efficient metabolism in order to maximize energy production yield in poor diet. If nutrient resource increases, a metabolic shift from efficient metabolism (respiration) to inefficient metabolism (fermentation) is reflecting a minimal cost principle of living systems to optimize fitness. This is known as the Crabtree/Warburg effect. Identifying a model that describes the population dynamics of cells and the input growth condition are the goals of this study. Proof of principle has been constructed using a battery of growth experiments on Crabtree-positive yeasts–Saccharomyces under various conditions of glucose in aerobic and micro-aerobic conditions. General cell growth model estimating metabolic shift has been constructed based on an Auto Regressive approach. Keywords: Yeast, Population dynamics, Modeling, Identification
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