{"title":"超氧化物歧化酶对大鼠脑线粒体存在下7,8 -二羟氯丙嗪自氧化的影响。","authors":"S A Tjioe, A A Manian, J J O'Neill","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>7,8-Dihydroxychlorpromazine 7,8-diOH-CPZ) is known to undergo auto-oxidation when exposed to air. Hydrogen peroxide is formed during this process, and the amount formed can be calculated from the amount of oxygen produced upon the addition of catalase. In the presence of superoxide dismutase the rate of oxidation of the CPZ metabolite is accelerated, accompanied by an increased production of hydrogen peroxide. When similar incubation are carried out with rat brain mitochondria present, hydrogen peroxide production is no longer detectable. The implications of this finding with regard to in vivo hydrogen peroxide production during the auto-oxidation of 7,8-diOH-CPZ are discussed. A preliminary report has been presented (1).</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 4","pages":"373-81"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of superoxide dismutase on the auto-oxidation of 7, 8-dihydroxychlorpromazine in the presence of rat brain mitochondria.\",\"authors\":\"S A Tjioe, A A Manian, J J O'Neill\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>7,8-Dihydroxychlorpromazine 7,8-diOH-CPZ) is known to undergo auto-oxidation when exposed to air. Hydrogen peroxide is formed during this process, and the amount formed can be calculated from the amount of oxygen produced upon the addition of catalase. In the presence of superoxide dismutase the rate of oxidation of the CPZ metabolite is accelerated, accompanied by an increased production of hydrogen peroxide. When similar incubation are carried out with rat brain mitochondria present, hydrogen peroxide production is no longer detectable. The implications of this finding with regard to in vivo hydrogen peroxide production during the auto-oxidation of 7,8-diOH-CPZ are discussed. A preliminary report has been presented (1).</p>\",\"PeriodicalId\":76387,\"journal\":{\"name\":\"Psychopharmacology communications\",\"volume\":\"1 4\",\"pages\":\"373-81\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology communications","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of superoxide dismutase on the auto-oxidation of 7, 8-dihydroxychlorpromazine in the presence of rat brain mitochondria.
7,8-Dihydroxychlorpromazine 7,8-diOH-CPZ) is known to undergo auto-oxidation when exposed to air. Hydrogen peroxide is formed during this process, and the amount formed can be calculated from the amount of oxygen produced upon the addition of catalase. In the presence of superoxide dismutase the rate of oxidation of the CPZ metabolite is accelerated, accompanied by an increased production of hydrogen peroxide. When similar incubation are carried out with rat brain mitochondria present, hydrogen peroxide production is no longer detectable. The implications of this finding with regard to in vivo hydrogen peroxide production during the auto-oxidation of 7,8-diOH-CPZ are discussed. A preliminary report has been presented (1).
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