构建生物信息学工作流程的智能系统

A. Fiannaca, S. Gaglio, M. L. Rosa, R. Rizzo, A. Urso
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引用次数: 2

摘要

本文介绍了一种新的智能系统,用于支持研究人员开发生物信息学实验工作流程。所提出的系统能够提出一个或多个策略,以解决所选择的问题,并支持用户在复杂实验的工作流组装中,使用知识库,表示有关应用领域的专业知识,以及基于规则的决策活动系统。此外,该系统可以在不同的抽象层表示该工作流,使用户从实现细节中解脱出来,并帮助他正确配置算法。为了展示所提出的工作流表示的主要特征,给出了一个从蛋白质-蛋白质相互作用网络中提取蛋白质复合物的示例工作流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Intelligent System for Building Bioinformatics Workflows
In this paper a new intelligent system designed to support the researcher in the development of a workflow for bioinformatics experiments is presented. The proposed system is capable to suggest one or more strategies in order to resolve the selected problem and to support the user in the assembly of a workflow for complex experiments, using a a Knowledge base, representing the expertise about the application domain, and a Rule-Based system for decision-making activity. Moreover, the system can represent this workflow at different abstraction layers, freeing the user from implementation details and assisting him in the correct configuration of the algorithms. A sample workflow for protein complex extraction from protein-protein interaction network is presented in order to show the main features of the proposed workflow representation.
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