{"title":"氯硝西泮在人体中的剂量范围研究。","authors":"L E Hollister","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A potent benzodiazepin derivative, clonazepam, was studied over a range of single doses to determine tolerance for the drug. The best tolerated doses were 0.5 and 1 mg. Higher doses were associated with considerable evidence of sedation, more easily detected by clinical questioning and observation than by commonly used self-reporting scales or motor tests.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 1","pages":"89-92"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dose-ranging studies of clonazepam in man.\",\"authors\":\"L E Hollister\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A potent benzodiazepin derivative, clonazepam, was studied over a range of single doses to determine tolerance for the drug. The best tolerated doses were 0.5 and 1 mg. Higher doses were associated with considerable evidence of sedation, more easily detected by clinical questioning and observation than by commonly used self-reporting scales or motor tests.</p>\",\"PeriodicalId\":76387,\"journal\":{\"name\":\"Psychopharmacology communications\",\"volume\":\"1 1\",\"pages\":\"89-92\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology communications","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A potent benzodiazepin derivative, clonazepam, was studied over a range of single doses to determine tolerance for the drug. The best tolerated doses were 0.5 and 1 mg. Higher doses were associated with considerable evidence of sedation, more easily detected by clinical questioning and observation than by commonly used self-reporting scales or motor tests.
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