{"title":"5,7-二羟色胺对大鼠脑区域色氨酸羟化酶影响的发育研究。","authors":"H G Baumgarten, S J Victor, W Lovenberg","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Tryptophan hydroxylase activity rises rapidly after birth in 5 distinct regions of the rat CNS. Near-adult levels of activity are recorded by 22 days of age in the cell-body rich regions of the brainstem and by 42 days in the terminal-rich areas, hypothalamus and remaining forebrain. The intracisternal injection of 40 mug 5,7-dihydroxytryptamine on day 2 after birth results in a near-total depletion of tryptophan hydroxylase in all CNS regions analyzed 6 or 12 days after drug administration. Enzyme activity recovers (to 11-24% of age matched controls) between day 12 and 20 after 5,7-dihydroxytryptamine in hypothalamus, midbrain and pons medulla oblongata. The growth of 5,7-DHT-treated animals is retarded between 3 and 40 days after drug administration.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 1","pages":"75-88"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A developmental study of the effects of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase in rat brain.\",\"authors\":\"H G Baumgarten, S J Victor, W Lovenberg\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tryptophan hydroxylase activity rises rapidly after birth in 5 distinct regions of the rat CNS. Near-adult levels of activity are recorded by 22 days of age in the cell-body rich regions of the brainstem and by 42 days in the terminal-rich areas, hypothalamus and remaining forebrain. The intracisternal injection of 40 mug 5,7-dihydroxytryptamine on day 2 after birth results in a near-total depletion of tryptophan hydroxylase in all CNS regions analyzed 6 or 12 days after drug administration. Enzyme activity recovers (to 11-24% of age matched controls) between day 12 and 20 after 5,7-dihydroxytryptamine in hypothalamus, midbrain and pons medulla oblongata. The growth of 5,7-DHT-treated animals is retarded between 3 and 40 days after drug administration.</p>\",\"PeriodicalId\":76387,\"journal\":{\"name\":\"Psychopharmacology communications\",\"volume\":\"1 1\",\"pages\":\"75-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology communications","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A developmental study of the effects of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase in rat brain.
Tryptophan hydroxylase activity rises rapidly after birth in 5 distinct regions of the rat CNS. Near-adult levels of activity are recorded by 22 days of age in the cell-body rich regions of the brainstem and by 42 days in the terminal-rich areas, hypothalamus and remaining forebrain. The intracisternal injection of 40 mug 5,7-dihydroxytryptamine on day 2 after birth results in a near-total depletion of tryptophan hydroxylase in all CNS regions analyzed 6 or 12 days after drug administration. Enzyme activity recovers (to 11-24% of age matched controls) between day 12 and 20 after 5,7-dihydroxytryptamine in hypothalamus, midbrain and pons medulla oblongata. The growth of 5,7-DHT-treated animals is retarded between 3 and 40 days after drug administration.
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