发光二极管刺激线粒体细胞色素c氧化酶对成纤维细胞增殖的影响

2010 IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES) Pub Date : 2010-11-01 DOI:10.1109/IECBES.2010.5742215

Yue-Feng Hsieh, J. Hsieh, R. Ruaan, E. Yeong, Y. Chou

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引用次数: 1

摘要

本研究旨在探讨细胞色素c与成纤维细胞增殖的关系。叠氮化钠阻断了细胞色素a3向CuB的电子传递，瓦巴因抑制了细胞膜上Na+， K+- atp酶的作用。叠氮化钠和瓦巴因处理后刺激发光二极管，研究细胞色素c是否与成纤维细胞增殖有关。我们还了解了两种抑制剂是否同时影响ATP的合成。研究结果将揭示成纤维细胞在发光二极管刺激下的增殖是否与线粒体中ATP合成有关。此外，我们还证实了发光二极管刺激成纤维细胞增殖的机制。

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Effect of fibroblasts proliferation by light-emitting diode stimulation via cytochrome c oxidase of mitochondria

The objective of the project was investigated that the relationships between cytochrome c and fibroblasts proliferation. The electron transport from cytochrome a3 to CuB was blocked by sodium azide and the action of Na+, K+-ATPase in cell membrane was inhibited by ouabain. Light emitting diode was stimulated after sodium azide and ouabain treatment to investigate whether cytochrome c was related to fibroblasts proliferation. We also realized whether two inhibitors affected ATP synthesis at the same time. The results will be realized whether fibroblasts proliferation by light emitting diode stimulation was related to ATP synthesis in mitochondria. Furthermore, the mechanism of fibroblasts proliferation by light emitting diode stimulation was also demonstrated.

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2010 IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES)

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