G. J. Shah, P. Chiou, J. Gong, A. Ohta, J. B. Chou, Ming C. Wu, C. Kim
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Integrating Optoelectronic Tweezers for Individual Particle Manipulation with Digital Microfluidics Using Electrowetting-On-Dielectric (EWOD)
This paper presents the integration of two powerful technologies: manipulation of droplets (i.e., digital microfluidics) using electrowettingon-dielectric (EWOD) and manipulation of individual particle inside the droplets using optoelectronic tweezers (OET). A novel platform for maintaining a viable cell culture environment is proposed as an application example, in which EWOD operations bring droplets containing cells, medium and waste into and out of the cell environment and OET operations address and manipulate the individual cells in coordination with the fluidic operations. Functions of EWOD and OET required to realize the concept are demonstrated.
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