{"title":"呼吸","authors":"Jesús Alan, MD Guardado Vindiola, Gisela Viviana, MD Licon Martinez, Marina Estrada-Rodriguez, Katya Lorena Wilhelmy-Ledesma, Joaquin Córdova Erberk, Álvaro Lozano Castañeda, MD MSc Miguel Angel Gaxiola-García, MD Hiram Javier Jaramillo-Ramírez","doi":"10.32388/w5ppdp","DOIUrl":null,"url":null,"abstract":"Background: The TMPRSS2 protein is an entry pathway for SARS-CoV-2, its expression is up-regulated by testosterone. Men have 7 to 8 times higher serum testosterone than women. We propose that patients hospitalized with COVID-19, with higher levels of testosterone, have worse outcomes than those with lower levels. Methods: A prospective, observational analysis of patients over 18-years-old with COVID-19 admitted to the internal medicine department in Mexicali’s General Hospital from January to April 2021. Results: 49 patients included, 32 men with a mean free testosterone of 2.95 pg/ml; 17 women with a mean of 1.08 pg/ml (p = 0.0002). 16 patients survived, with a mean of 3.21 pg/ml while 33 patients died with a mean of 1.82 pg/ ml (p = 0.007). In the male subgroup, the mean of survivors was 3.95 pg/m, in non-survivors was 2.43 pg/ml (p = 0.017). In women, the survivors mean was 1.85 pg/ml while in non-survivors it was 0.66 pg/ml (p = 0.01). Conclusions: Our study showed that hospitalized patients with COVID-19, with lower levels of free testosterone have worse outcomes than those with higher levels.","PeriodicalId":340620,"journal":{"name":"Peripheral Brain for the Pharmacist, 2021-2022","volume":"15 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Respiratory\",\"authors\":\"Jesús Alan, MD Guardado Vindiola, Gisela Viviana, MD Licon Martinez, Marina Estrada-Rodriguez, Katya Lorena Wilhelmy-Ledesma, Joaquin Córdova Erberk, Álvaro Lozano Castañeda, MD MSc Miguel Angel Gaxiola-García, MD Hiram Javier Jaramillo-Ramírez\",\"doi\":\"10.32388/w5ppdp\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The TMPRSS2 protein is an entry pathway for SARS-CoV-2, its expression is up-regulated by testosterone. Men have 7 to 8 times higher serum testosterone than women. We propose that patients hospitalized with COVID-19, with higher levels of testosterone, have worse outcomes than those with lower levels. Methods: A prospective, observational analysis of patients over 18-years-old with COVID-19 admitted to the internal medicine department in Mexicali’s General Hospital from January to April 2021. Results: 49 patients included, 32 men with a mean free testosterone of 2.95 pg/ml; 17 women with a mean of 1.08 pg/ml (p = 0.0002). 16 patients survived, with a mean of 3.21 pg/ml while 33 patients died with a mean of 1.82 pg/ ml (p = 0.007). In the male subgroup, the mean of survivors was 3.95 pg/m, in non-survivors was 2.43 pg/ml (p = 0.017). In women, the survivors mean was 1.85 pg/ml while in non-survivors it was 0.66 pg/ml (p = 0.01). Conclusions: Our study showed that hospitalized patients with COVID-19, with lower levels of free testosterone have worse outcomes than those with higher levels.\",\"PeriodicalId\":340620,\"journal\":{\"name\":\"Peripheral Brain for the Pharmacist, 2021-2022\",\"volume\":\"15 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Peripheral Brain for the Pharmacist, 2021-2022\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32388/w5ppdp\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Peripheral Brain for the Pharmacist, 2021-2022","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32388/w5ppdp","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Background: The TMPRSS2 protein is an entry pathway for SARS-CoV-2, its expression is up-regulated by testosterone. Men have 7 to 8 times higher serum testosterone than women. We propose that patients hospitalized with COVID-19, with higher levels of testosterone, have worse outcomes than those with lower levels. Methods: A prospective, observational analysis of patients over 18-years-old with COVID-19 admitted to the internal medicine department in Mexicali’s General Hospital from January to April 2021. Results: 49 patients included, 32 men with a mean free testosterone of 2.95 pg/ml; 17 women with a mean of 1.08 pg/ml (p = 0.0002). 16 patients survived, with a mean of 3.21 pg/ml while 33 patients died with a mean of 1.82 pg/ ml (p = 0.007). In the male subgroup, the mean of survivors was 3.95 pg/m, in non-survivors was 2.43 pg/ml (p = 0.017). In women, the survivors mean was 1.85 pg/ml while in non-survivors it was 0.66 pg/ml (p = 0.01). Conclusions: Our study showed that hospitalized patients with COVID-19, with lower levels of free testosterone have worse outcomes than those with higher levels.
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