{"title":"单次和每日两次给药时血浆苯妥英水平的波动。","authors":"F J Vajda, J Merory, P F Bladin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.</p>","PeriodicalId":76351,"journal":{"name":"Proceedings of the Australian Association of Neurologists","volume":"12 ","pages":"61-4"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.\",\"authors\":\"F J Vajda, J Merory, P F Bladin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.</p>\",\"PeriodicalId\":76351,\"journal\":{\"name\":\"Proceedings of the Australian Association of Neurologists\",\"volume\":\"12 \",\"pages\":\"61-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Australian Association of Neurologists\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Australian Association of Neurologists","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
Eight chronic refractory epileptics were studied with regard to frequency of administration of phenytoin. There were no excessive fluctuations in plasma levels when the total drug dose was given as a single daily dose, and the clinical state of the patients was unchanged from that on twice daily dosage.
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