气相色谱法测定血液和尿液中尼古丁和可替宁的显微方法。结果来自不同的吸烟者]。

European journal of toxicology and environmental hygiene. Journal europeen de toxicologie Pub Date : 1975-09-01

C Dumas, R Badré, A Viala, J P Cano, R Guillerm

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引用次数: 0

摘要

采用气相色谱法，以二苯胺为内标，用ucono - polar 50 HB 2000碱化柱和特异N检测器测定吸烟者血浆和尿液中的尼古丁和可替宁。发展了提取和色谱分析技术。正确测定的极限值为:尼古丁0.2纳克，可替宁1纳克。结果表明，尼古丁和可替宁进入血液的速度非常快。他们证实了尿中尼古丁的快速排泄和可替宁的缓慢排泄，以及排泄量和尿流之间的关系。

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[A micromethod for determination of nicotine and cotinine in blood and urine by gas chromatography. Results obtained from various smokers].

The determination of nicotine and cotinine in plasma and urines of smokers is carried out by gas-chromatography with an Ucon-Polar 50 HB 2000 alkalinized column and a specific N detector, using diphenylamine as internal standard. The technique for extraction and chromatographic analysis is developed. The limit values for a correct determination are : 0,2 ng for nicotine and 1 ng for cotinine. The results show that the transit of nicotine and cotinine into the blood is very fast. They confirm the rapidity of the urinary excretion of nicotine, the slowness of that of cotinine, and the relation between the eliminated amounts and the urinary flow.

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European journal of toxicology and environmental hygiene. Journal europeen de toxicologie

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