Electrocardiographic Prediction of Culprit Artery in Inferior ST-Segment Elevation Myocardial Infarction: Looks can Be Deceiving

A 60-year-old female patient, a cigarette smoker with a history of hyperlipidemia presented to the hospital with a 1-h episode of retrosternal chest pain. Physical examination revealed nothing remarkable. Electrocardiography (ECG) showed >0.1 mV ST-segment elevation (STE) in II, aVF, III, and V6, and ST-segment depression (STD) in aVL, I, and V1 to V4 ( Figure 1A ), ≥0.05 mV STE in V5R and V6R ( Figure 1B ), and >0.05 mV STE in V7 to V9 ( Figure 1C ). The patient received a diagnosis of infero-postero-lateral wall STEmyocardial infarction (MI) and was referred for emergency coronary angiography. Which is the culprit artery, based on the ECG findings? Interpretation of the ECG with use of vector concepts reveals an ST-segment vector pointing downward and somewhat rightward between +90° and +120° (STE III > II and STD aVL > I) as well as backward with less STD in V1 to V3 than STE in the inferior leads. Consequently, based on conventional ECG criteria, the right coronary artery (RCA) was most likely the culprit artery. 1-3 Importantly, the ECG also reveals about 0.1 mV STD in aVR, that is a lead facing through the left ventricular cavity, the apex, and lateral wall and is directionally opposite to I, II, V5, and V6, with the latter showing about 0.2 mV STE in this case. Therefore, the ECG indicates extension of the infarction to the apical inferior and apical lateral walls thereby suggesting the presence of a large posterior-lateral left ventricular branch (PLVB). 4 The overall ECG evidence, including an isoelectric ST-segment in V4R and STD in V3 to V4 and STE in V7 to V9, which indicate extension of the infarction to the inferobasal (formerly posterior) wall can be justified by distal occlusion of a dominant RCA supplying a large PLVB. Nonetheless, the inferior-lateral wall is also supplied by the LCx artery, the occlusion of which may also result in STD in aVR. Indeed, the latter ECG sign has been reported to be more common in LCx artery-related than RCA-related MI. 4 Furthermore, in a