吊坠网络中人类ips衍生的心脏三维球体的同步阻抗谱和刺激

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) Pub Date : 2015-03-02 DOI:10.1109/MEMSYS.2015.7050928

S. C. Burgel, Yannick R. F. Schmid, I. Agarkova, D. Fluri, J. Kelm, A. Hierlemann, O. Frey

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引用次数: 4

摘要

在这里，我们展示了电刺激集成在悬垂网络中的人类ips衍生的心脏三维球体的电阻抗谱(EIS)数据。显微镜下的跳动球体视频与同步获得的EIS记录相关联。对于刺激，球体暴露在连续的正弦电场中-与传统脉冲序列相反。这个刺激场是通过与EIS记录相同的电极提供的。我们的测量结果显示，在调整刺激信号幅度时，跳动频率调制。

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Simultaneous impedance spectroscopy and stimulation of human iPS-derived cardiac 3D spheroids in hanging-drop networks

Here, we present electrical impedance spectroscopy (EIS) data of human iPS-derived cardiac 3D spheroids with electric stimulation integrated in a hanging drop network. Microscopy videos of the beating spheroids were correlated with synchronously obtained EIS recordings. For stimulation, the spheroid was exposed to a continuous sinusoidal electric field - in contrast to traditional pulse trains. This stimulating field was supplied via the same electrodes that were used for the EIS recordings. Our measurements revealed a beating frequency modulation upon tuning the stimulation signal amplitude.

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2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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