Simulation of the Influence of Parameters on Simulated Moving Bed

Abstract—Chromatographic separation by simulated moving bed (SMB) is an important skill for the modern material separation process. It is widely used in chemical and medical pharmaceutical industries. It has been recognized as a clean and green technology in the chromatographic application. In order to achieve a precision control for SMB, the influence and the effect of parameters to the final axial separation is an important study for realizing the behaviors of SMB. However, such kind of study is hardly to implement in the real SMB system due to the high experimental cost and the sensitivity of parameters. Thus, the computer simulation for studying the influence parameters to the final axial separation was implemented and presented in this paper. From the simulation results shown, the whole study is quite consistent with the actual behavior of SMB. It indeed has a great help for the future’s development of precision control of SMB.