基于Gwo的乐观特征选择预测晚期肝纤维化

S. Singaravelan, A. Sathya, V. Harini, D. Murugan
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摘要

根据联合国的最新估计,截至2019年1月,印度现有人口为1,362,255,678人[1]。世界范围内的检查计算出,印度有870万人患有慢性肝炎。在印度,慢性肝炎占肝脏恶性生长的12- 32%,占肝硬化病例的10- 20%。绝大多数患有乙型或丙型肝炎的人对疾病一无所知,并且处于造成肝硬化或肝脏恶性生长的真正危险之中。机器学习比其他传统方法(如活检)更适合一些程序。本文对各种机器学习方法进行评估,利用患者血液报告预测晚期肝纤维化,建立优化和分类模型。METAVIR评分是一种用于评估慢性肝炎患者肝活检检查中纤维化严重程度的工具。根据METAVIR评分[2,3,4]将慢性肝炎分为三部分,第一阶段为轻度,第二阶段为中度,第三阶段为纤维化晚期。建立了灰狼优化模型、随机森林分类器模型和决策树模型。评估ROC曲线和混淆矩阵来比较所提出方法的准确性。
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GWO BASED OPTIMISTIC FEATURE SELECTION FOR PREDICTION OF ADVANCED LIVER FIBROSIS
The present populace of India is 1,362,255,678 as of January, 2019, in view of the most recent United Nations estimates [1]. Worldwide examinations calculate that there are 8.7 million individuals living with chronic Hepatitis in India. Chronic Hepatitis disease represents 12-32 per cent of liver malignant growth and 10-20 per cent of cirrhosis cases in India. The vast majority with constant Hepatitis B or C are ignorant of diseases and are at genuine danger of creating cirrhosis or liver malignant growth.Machine learning fits a few procedures superior to other traditional methods like Biopsy. This paper evaluate various machine learning methods to predict advanced liver fibrosis by using patient’s blood report to build up the optimization and classification models. The METAVIR score is a device used to assess the seriousness of fibrosis seen on a liver biopsy test from a human who has chronic hepatitis. Based on the METAVIR score [2,3,4] chronic hepatitis divided into three parts, first one is classified as mild stage, second one is moderate stage and third one is advanced stage of fibrosis. Grey Wolf Optimization, Random Forest Classifier and Decision tree procedure models forpropelled fibrosis chance expectation were produced. ROC curve and confusion matrix was evaluated to compare the accuracy of proposed methods.
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