自身免疫性疾病的精准医学

A. Ajayi, Oluwadunsin Iyanuoluwa Adebayo, Emmanuel Tayo Adebayo
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引用次数: 1

摘要

基于基因组的信息是精确治疗的关键,被称为个性化医疗。它在自身免疫性疾病治疗中的应用将带来医学上所需的突破。自身免疫性疾病是人体免疫系统识别并产生针对自身抗原的免疫反应的疾病状况。在自身免疫性疾病的临床管理中,利用精准医学数据的途径多种多样;这包括诊断、预后、分层和治疗反应预测。存在不同的标记来指导临床决策,而其他一些仍在确定和提出。本章重点介绍了自身免疫性疾病精准医学中的数据和数据库,以及数据共享的途径。讨论了自身免疫性疾病的精准医学,并考虑了不同生物标志物在自身免疫性疾病的诊断、预后、分层和反应监测中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Precision Medicine of Autoimmune Diseases
Genomic-based information is an essential key to precise therapy referred to as personalized medicine. Its application in autoimmune disease treatment will bring the required breakthrough in medicine. Autoimmune diseases are the disease conditions where the body’s immune system recognizes and generate an immune response against self-antigens. There exist different approaches of which precision medicine data can be utilized in the clinical management of autoimmune diseases; this includes diagnosis, prognosis, stratification and treatment response prediction. Different markers exist to guide clinical decision while several others are still being identified and proposed. This chapter highlights data and databases in precision medicine of autoimmune diseases and the pathway for data sharing. The precision medicine of selected autoimmune diseases was discussed, and the different biomarkers utilized in the diagnosis, prognosis, stratification and response monitoring of such condition were considered.
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