{"title":"塑料微流控芯片上血凝性能的改进","authors":"Mahdee Samae, Somyot Chirasatitsin","doi":"10.1109/BMEICON.2018.8609930","DOIUrl":null,"url":null,"abstract":"Hemagglutination is a specific form of agglutination that involves red blood cells (RBCs). It has a limitation in view of emergency and point-of-care diagnoses (POCD) due to the requirement of large scale equipment and long time to result. In this study, a plastic microfluidic chip (P-μFC) included dried antibody-embedded was introduced. The hemagglutination reaction was enhanced by increasing amount of antibody dissolved in a reaction chamber. Within 2 minutes, the blood agglutination reaction was evaluated quantitatively by image processing. Moreover, a protein stabilizers of sugars were employed to increase the solubility of dried antibody so that the reaction with dried antibody was equivalent to which with fresh antibody.","PeriodicalId":232271,"journal":{"name":"2018 11th Biomedical Engineering International Conference (BMEiCON)","volume":"167 2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Improvement of Hemagglutination on Plastic Microfluidic Chip\",\"authors\":\"Mahdee Samae, Somyot Chirasatitsin\",\"doi\":\"10.1109/BMEICON.2018.8609930\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hemagglutination is a specific form of agglutination that involves red blood cells (RBCs). It has a limitation in view of emergency and point-of-care diagnoses (POCD) due to the requirement of large scale equipment and long time to result. In this study, a plastic microfluidic chip (P-μFC) included dried antibody-embedded was introduced. The hemagglutination reaction was enhanced by increasing amount of antibody dissolved in a reaction chamber. Within 2 minutes, the blood agglutination reaction was evaluated quantitatively by image processing. Moreover, a protein stabilizers of sugars were employed to increase the solubility of dried antibody so that the reaction with dried antibody was equivalent to which with fresh antibody.\",\"PeriodicalId\":232271,\"journal\":{\"name\":\"2018 11th Biomedical Engineering International Conference (BMEiCON)\",\"volume\":\"167 2 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2018 11th Biomedical Engineering International Conference (BMEiCON)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BMEICON.2018.8609930\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 11th Biomedical Engineering International Conference (BMEiCON)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BMEICON.2018.8609930","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Improvement of Hemagglutination on Plastic Microfluidic Chip
Hemagglutination is a specific form of agglutination that involves red blood cells (RBCs). It has a limitation in view of emergency and point-of-care diagnoses (POCD) due to the requirement of large scale equipment and long time to result. In this study, a plastic microfluidic chip (P-μFC) included dried antibody-embedded was introduced. The hemagglutination reaction was enhanced by increasing amount of antibody dissolved in a reaction chamber. Within 2 minutes, the blood agglutination reaction was evaluated quantitatively by image processing. Moreover, a protein stabilizers of sugars were employed to increase the solubility of dried antibody so that the reaction with dried antibody was equivalent to which with fresh antibody.
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