居住在切尔诺贝利隔离区附近儿童同型半胱氨酸代谢的遗传控制

Yu.I. Bandazhevskyi, N. Dubova
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摘要

研究目的:在切尔诺贝利核电站事故发生35年后,确定叶酸周期基因与乌克兰基辅地区Ivankivskyi地区儿童高同型半胱氨酸血症发生的关系。研究方法。免疫化学,数学和统计。结果。测定了基辅地区Ivankivskyi区的217名12-17岁儿童的同型半胱氨酸水平,以及叶酸循环的遗传多态性。在接受检查的人中,65.44%(217人中有142人)检测到血液中同型半胱氨酸过量超过10 μ mol/l(高同型半胱氨酸血症状态),在男孩中为69.79%(96人中有67人),在女孩中为61.98%(121人中有75人)。高同型半胱氨酸血症病例在基本多态性MTHFR的儿童亚组中所占比例最大:677TT,占94.44%。在大多数情况下,儿童高同型半胱氨酸血症与环境因素有关,包括放射性元素及其衰变产物。预防生活在切尔诺贝利核电站事故影响地区的儿童高同型半胱氨酸血症及其后果的系统应包括定期监测儿童体内和当地生产的食物中的放射性核素含量、血液中同型半胱氨酸的含量以及评估叶酸循环基因的状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic control of homocysteine metabolism in children living near the chоrnobyl exclusion zone
The aim of study: to determine the involvement of folate cycle genes in the occurrence of hyperhomocysteinemia in children from Ivankivskyi district of Kyiv region of Ukraine 35 years after the accident at the Chornobyl nuclear power plant. Research methods. Immunochemical, mathematical and statistical. Results. Homocysteine levels were determined in 217 children aged 12-17 from Ivankivskyi district of Kyiv region, as well as genetic polymorphisms of the folate cycle. An excess of homocysteine in the blood over 10 µmol/l (a state of hyperhomocysteinemia) was detected in 65.44 % (142 out of 217) of those examined, among boys – 69.79 % (67 out of 96), among girls – 61.98 % (75 out of 121). The largest proportion of hyperhomocysteinemia cases was registered in the subgroup of children with the basic polymorphism MTHFR: 677TT – 94.44 % of cases. In most cases, hyperhomocysteinemia in children was associated with an environmental factor, including radioactive elements and their decay products. The system for the prevention of hyperhomocysteinemia and its consequences in children living in areas affected by the accident at the Chornobyl nuclear power plant should include regular monitoring of the content of radionuclides in the body of children and locally produced food, the content of homocysteine in the blood, and assessment of the state of folate cycle genes.
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