{"title":"不同镇静药物对骨髓细胞增殖的影响。初步结果。","authors":"C Dresch, O Poirier, J Minc, C Bismuth","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Several drugs were assayed for their effect on bone marrow hematopoïetic cells proliferation. Chlorpromazine, barbiturates and benzopiperidine were found active only at toxic dosage. Propranolol and fluanison seem in the preliminary studies to lessen 3 H-thymidine incorporation in vitro at non toxic concentration.</p>","PeriodicalId":75837,"journal":{"name":"European journal of toxicology and environmental hygiene. Journal europeen de toxicologie","volume":"8 4","pages":"252-7"},"PeriodicalIF":0.0000,"publicationDate":"1975-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of different sedative drugs on the proliferation of bone marrow cells. Preliminary results.\",\"authors\":\"C Dresch, O Poirier, J Minc, C Bismuth\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Several drugs were assayed for their effect on bone marrow hematopoïetic cells proliferation. Chlorpromazine, barbiturates and benzopiperidine were found active only at toxic dosage. Propranolol and fluanison seem in the preliminary studies to lessen 3 H-thymidine incorporation in vitro at non toxic concentration.</p>\",\"PeriodicalId\":75837,\"journal\":{\"name\":\"European journal of toxicology and environmental hygiene. Journal europeen de toxicologie\",\"volume\":\"8 4\",\"pages\":\"252-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of toxicology and environmental hygiene. Journal europeen de toxicologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of toxicology and environmental hygiene. Journal europeen de toxicologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
研究了几种药物对骨髓hematopoïetic细胞增殖的影响。氯丙嗪、巴比妥类药物和苯并哌啶仅在中毒剂量下才有活性。初步研究表明,心得安和氟尼松在体外无毒浓度下可减少3 - h -胸腺嘧啶的掺入。
Effect of different sedative drugs on the proliferation of bone marrow cells. Preliminary results.
Several drugs were assayed for their effect on bone marrow hematopoïetic cells proliferation. Chlorpromazine, barbiturates and benzopiperidine were found active only at toxic dosage. Propranolol and fluanison seem in the preliminary studies to lessen 3 H-thymidine incorporation in vitro at non toxic concentration.