重症肌无力患者抑郁的筛查

Bakri H. Elsheikh, Obinna Moneme, M. Freimer, J. Kissel, W. Arnold
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摘要

关于重症肌无力(MG)患者抑郁患病率的报道相互矛盾。躯体症状对筛查评估的影响并不明显。我们调查了MG患者抑郁的躯体和非躯体症状的频率。我们还利用疾病严重程度和生活质量指标探讨了抑郁症和MG之间的关系。方法:采用贝克抑郁量表2 (BDI-II)和bdi -初级保健(BDI-PC)调查、修正Rankin量表、MGFA分级、MG- mmt、MG- adl和MG- qol15对三组参与者(MG、健康和疾病对照)进行前瞻性评估。结果:共纳入31名MG、29名疾病对照和30名健康对照。BDI-II指示的抑郁频率MG组为48%(15/31),疾病对照组为31%(9/29),差异无统计学意义[p=0.17]。然而,我们发现频率明显高于健康对照组10% (3/30)[p=0.001]。相比之下,BDI-PC显示的抑郁频率在MG组为29%(9/31),疾病对照组为24% (7/29)[p=0.77],健康对照组为10% (3/30)[p=0.08]。使用BDI-II量表,抑郁的MG参与者在MG- mmt, MG- adl和MG- qol15上的得分高于无抑郁的参与者。使用BDI-PC评分,MG-ADL和MG-QOL15评分的差异仍然显著。讨论:这些发现表明,包括身体症状的抑郁症筛查评估高估了MG和慢性自身免疫性神经肌肉疾病的抑郁症。自我报告抑郁的频率越高,疾病严重程度越高,生活质量越低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening for depression in myasthenia gravis
Introduction: There are conflicting reports of depression prevalence in myasthenia gravis (MG). The influence of somatic symptoms on screening assessments is not apparent. We investigated the frequency of somatic and non-somatic symptoms of depression in MG. We also explored the relationship between depression and MG using disease severity and quality of life measures. Methods: Three cohorts of participants (MG, healthy and disease controls) were prospectively assessed with the Beck Depression Inventory 2 (BDI-II) and BDI-Primary Care (BDI-PC) surveys, modified Rankin Scale, MGFA classification, MG-MMT, MG-ADL and MG-QOL15. Results: A total of 31 MG, 29 disease controls, and 30 healthy controls were enrolled. Depression frequency indicated by BDI-II in MG 48% (15/31) and disease control 31% (9/29) was not significantly different [p=0.17]. However, we found a significantly higher frequency than healthy controls 10% (3/30) [p=0.001]. In contrast, depression frequency indicated by BDI-PC was similar in the MG 29% (9/31) and disease controls MG, 24% (7/29)[p=0.77] as well as the healthy controls 10% (3/30) [p=0.08]. Using the BDI-II scale, participants with MG who were depressed had higher scores on MG-MMT, MG-ADL, and MG-QOL15 than those who were not depressed. The difference in MG-ADL and MG-QOL15 scores remained significant using the BDI-PC score. Discussion: These findings suggest depression screening assessments that include physical symptoms overestimate depression in MG and chronic autoimmune neuromuscular disorders. A higher frequency of self-reported depression is associated with increasing disease severity and low quality of life.
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