基于规划/印记和嵌入现象的区域DOHaD中心的必要性

V. I. Goudochnikov
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引用次数: 0

摘要

本文简要回顾了几种精神神经药物和糖皮质激素对发育中的动物和人类生长抑制作用的证据,并结合我们自己在实验模型中获得的数据,以及在流行病学研究中证实女性在情感障碍和某些精神神经药物消费引起的发病率中占主导地位。讨论了药物毒理学规划/印记和嵌入的新兴概念,证明了区域DOHaD中心的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The necessity of regional DOHaD centers based on programming/imprinting and embedding-like phenomena
A mini-review is presented for the evidence of growth-inhibitory effects of several psychoneurotropic drugs and glucocorticoids on developing animals and humans, together with our own data obtained in experimental models, as well as in epidemiologic studies confirming female predominance in morbidity caused by affective disorders and in consumption of some psychoneurotropic drugs. The emerging concepts of pharmacotoxicologic programming/imprinting and embedding are discussed, justifying the necessity of regional DOHaD centers.
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