老年慢性病患者药物不良反应风险评估

Godeliva Adriani Hendra, E. Monica, Ike Yossy Herawati
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引用次数: 1

摘要

导读:老年患者药物不良反应(ADR)发生率为老年患者的4-7倍。这也与引发药物相关问题的药代动力学和药效学变化有关。目的:本研究的目的是利用GerontoNET评分和老年人处方筛选工具(STOPP)标准评估老年慢性病患者的不良反应。方法:采用横断面研究,描述性分析。样本包括72名患者,年龄超过60岁,伴有慢性疾病,在Waluyo Jati Kraksaan医院住院。排除标准是转到重症监护室的患者。使用GerontoNet评分评估老年慢性病患者的不良反应风险,同时使用STOPP标准给老年患者错误的药物类型。GerontoNET评分中包含的变量是合并症³4(评分= 1),心力衰竭(评分= 1),肝脏疾病(评分= 1),药物数量如:£5(评分= 0);6 - 7(得分= 1);³8例(评分=4),不良反应史(评分=2),肾功能衰竭(评分=1)。结果:ADR危险因素最多的变量为用药次数³8种药物多达47例(65.3%),其中GerontoNET评分³4的患者多达70.8%。STOPP标准中包括的药物类型有氯吡格雷、阿立司特(氟达哌啶)、受体阻滞剂、非甾体抗炎药和速尿。结论:发生药品不良反应的危险因素为用药数量³8种药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk Assessment Of Adverse Drug Reactions In Elderly Patients With Chronic Diseases
Introduction: The adverse drug reaction (ADR) is 4-7 times more common in elderly patients.  That was also related to changes in pharmacokinetics and pharmacodynamics that triggered the emergence of Drug-Related Problems. Objective: The purpose of this study was to assess ADR in elderly patients with chronic diseases using the GerontoNET Score and the Screening Tool of Older People's Prescriptions (STOPP) criteria.  Methods: The research design used a cross-sectional study which was analyzed descriptively. The sample consisted of 72 patients, aged more than 60 years, accompanied by chronic diseases, and hospitalized at Waluyo Jati Kraksaan Hospital. The exclusion criteria were patients referred to the Intensive Care Unit.  Assessment to see the risk of ADR in elderly patients with chronic diseases using the GerontoNet Score while the wrong type of drug is given to elderly patients using the STOPP criteria. The variables contained in the GerontoNET Score are comorbid conditions ³4 (score= 1), heart failure (score= 1), liver disease (score = 1), the number of drugs such as: £5 (score= 0); 6-7 (score=1); ³8 (score=4), history of ADR (score=2), kidney failure (score=1).  Results: The variable with the most ADR risk factors was the number of drugs ³8 drugs as many as 47 patients (65.3%) with GerontoNET score ³4 as much as 70.8%.  The types of drugs included in the STOPP criteria are clopidogrel, Arixtra (fondaparinux), beta-blockers, NSAIDs, and furosemide.  Conclusion: The risk factor for ADR was the number of drugs ³8 drugs.
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