冠状病毒对肝脏的潜在影响:现有知识

Mandal Avishek
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摘要

由SARS-CoV-2引起的全球大流行COVID-19影响了数百万人。COVID-19以其呼吸道症状而闻名,但新的研究表明,它也可能影响包括肝脏在内的其他器官系统。本文综述了COVID-19与肝功能的关系。病毒通过肝脏表达的血管紧张素转换酶2 (ACE2)受体进入宿主细胞。因此,病毒感染和复制可能以肝脏为目标。病毒引起的炎症和细胞因子的产生也可能损害肝脏。ALT和AST升高是COVID-19患者中最常见的肝脏异常。肝功能检查异常往往预示着严重的疾病和不良的临床结果。COVID-19可能会加重NAFLD和慢性病毒性肝炎等已有肝脏疾病。包括抗病毒药物和皮质类固醇在内的COVID-19治疗引起的药物性肝损伤(DILI)使肝脏并发症护理复杂化。最近的调查还表明,COVID-19可能导致长期肝损伤。总之,COVID-19感染、免疫介导的损伤和治疗问题可能严重损害肝功能。优化患者治疗和发现靶向药物需要了解COVID-19的肝脏作用。为了减少COVID-19对肝功能的影响,需要进一步研究其机制和长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospective Coronavirus Liver Effects: Available Knowledge
The global pandemic COVID-19, caused by SARS-CoV-2, affected millions of people. COVID-19 is known for its respiratory symptoms, but new research reveals it may also affect other organ systems, including the liver. This abstract reviews COVID-19 and liver function. The virus enters host cells through liver-expressed angiotensin-converting enzyme 2 (ACE2) receptors. Thus, viral infection and replication may target the liver. Virus-induced inflammation and cytokine production may also harm the liver. ALT and AST elevations are the most prevalent liver abnormalities in COVID-19 patients. Liver function test abnormalities frequently indicate serious illness and poor clinical outcomes. COVID-19 may worsen pre-existing liver diseases such as NAFLD and chronic viral hepatitis. Drug-induced liver damage (DILI) from COVID-19 therapies including antivirals and corticosteroids complicates liver complications care. Recent investigations have also shown that COVID-19 may cause long-term liver damage. In conclusion, COVID-19 infection, immune-mediated damage, and treatment problems may severely compromise liver function. Optimizing patient treatment and discovering targeted medicines requires understanding COVID-19's liver role. To reduce the effects of COVID-19 on liver function, further study is required to understand the mechanisms and long-term effects.
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