Kinetics of muller's ratchet from adaptive landscape viewpoint

Background: The accumulation of deleterious mutations of a population directly contributes to the fate as to how long the population would exist. Muller's ratchet provides a quantitative framework to study the effect of accumulation. Adaptive landscape as a powerful concept in system biology provides a handle to describe complex and rare biological events. In this article we study the evolutionary process of a population exposed to Muller's ratchet from the new viewpoint of adaptive landscape which allows us estimate the single click of the ratchet starting with an intuitive understanding.