果蝇神经回路的交互式图形可视化

J. Sorger, K. Bühler, F. Schulze, Tianxiao Liu, B. Dickson
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引用次数: 35

摘要

神经科学家研究了普通果蝇黑腹果蝇大脑中神经回路的功能,以发现复杂行为是如何产生的。为了建立神经信息处理模型,需要了解单个神经元之间的潜在连接。当两个神经元的分支重叠时,连接就会发生。由于被检测的物体相互遮挡,传统的体积可视化很难通过分析重叠来判断连通性。因此,需要一种更抽象的表示形式。与一组神经科学家合作,我们设计并实现了neuroMap,这是一个交互式二维图形,以电路风格的接线图的形式呈现大脑及其相互联系。neuroMap提供了神经元之间所有可能连接的清晰结构概述,并提供了对底层神经元数据库进行交互式探索的手段。在本文中,我们讨论了形成神经地图的设计决策,并在与科学家的讨论中评估其应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
neuroMAP — Interactive graph-visualization of the fruit fly's neural circuit
Neuroscientists study the function of neural circuits in the brain of the common fruit fly Drosophila melanogaster to discover how complex behavior is generated. To establish models of neural information processing, knowledge about potential connections between individual neurons is required. Connections can occur when the arborizations of two neurons overlap. Judging connectivity by analyzing overlaps using traditional volumetric visualization is difficult since the examined objects occlude each other. A more abstract form of representation is therefore desirable. In collaboration with a group of neuroscientists, we designed and implemented neuroMap, an interactive two-dimensional graph that renders the brain and its interconnections in the form of a circuit-style wiring diagram. neuroMap provides a clearly structured overview of all possible connections between neurons and offers means for interactive exploration of the underlying neuronal database. In this paper, we discuss the design decisions that formed neuroMap and evaluate its application in discussions with the scientists.
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