多糖在病毒性疾病中作用的可能分子机制

E. Generalov, E. Simonenko, L. Yakovenko
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引用次数: 0

摘要

在过去的几十年里,大量的研究已经证实,从各种来源获得的多糖具有广泛的生物活性,包括抗病毒作用。本文主要介绍了多糖的抗病毒活性及其可能参与的细胞内信号通路、多糖的来源和种类、组成和结构的特点以及主要的生物活性类型。结合COVID-19大流行,本文更详细地讨论了该疾病的病原体SARS-CoV-2病毒的特征、与细胞受体的相互作用、疾病后果的分子机制以及多糖在该疾病中的可能的药用作用。展望未来,天然多糖可能被证明是各种病毒性疾病的有效治疗剂,与传统抗病毒药物相比,可能更有效且没有副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
POSSIBLE MOLECULAR MECHANISMS OF POLYSACCHARIDES ACTION IN VIRAL DISEASES
Over the past decades, numerous studies have established that polysaccharides obtained from various sources have a wide range of biological activities, including antiviral action. This paper presents data mainly on the antiviral activity of polysaccharides and intracellular signaling pathways that may be involved in its manifestation, some sources and types of polysaccharides, features of their composition and structure, and the main types of their biological activities are mentioned. In connection with the COVID-19 pandemic, the features of the causative agent of this disease, the SARS-CoV-2 virus, its interactions with cell receptors, the molecular mechanisms of the consequences of the disease and the possible medicinal effect of polysaccharides in this disease are considered in more detail. In prospect, natural polysaccharides may prove to be effective therapeutic agents for various viral diseases, perhaps more effective and without side effects in comparison with traditional antiviral drugs.
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